Prof. Dr. Stefan Gaubatz
Tel.: 0931 31-84138
Our main interest is transcriptional regulation of the mammalian cell cycle by the DREAM complex and Myb-MuvB (MMB). MMB together with the B-MYB transcription factor is a master activator of genes required for mitosis and cytokinesis.
We use biochemical and genetic methods to understand how DREAM, MuvB, B-MYB and its target genes contribute to normal proliferation, development and tumorigenesis.
Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci USA (in press)
Wolter P, Hanselmann S, Pattschull G, Schruf E, Gaubatz S (2017): Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy. Oncotarget. in press.
April 2017: Laura and Eva join the lab for their Bachelor thesis
June 2017: GAS2L3 paper accepted !
Bachelor- und Masterarbeiten ab sofort zu vergeben!